- Preparing For Appointments
- Contact Us
- Maps and Directions
- Clinical Trials
- Our Physicians
- Frequently Asked Questions
Events & Groups:
Join Us On Facebook.
Follow us on Twitter.
Clinical Trials
Did you know Clearview Cancer Institute has been involved in Clinical Research for over 18 years? Findings from clinical trial research have led to significant advances in cancer prevention and treatment, and Clearview offers numerous clinical trials whereby patients who volunteer for them receive innovative, state-of-the-art cancer care.
Colorectal Cancer
Amgen 20070509 - A Randomized , Multicenter, Phase 2 Study to Compare the Efficacy of Panitumumab in Combination with mFOLFOX6 to the Efficacy of Bevacizumab in Combination with mFOLFOX6, in patients with previously Untreated, KRAS Wild-type, Unresectable, Metastatic Colorectal Cancer.
Rationale:
- To estimate the treatment effect on progression free survival (PFS) of panitumimab relative to Bevacizumab in combination with mFOLFOX6 chemotherapy as first-line therapy or mCRC in patients with tumors expressing wildtype KRAS.
- To evaluate overall survival (OS), objective response (OR), duration of response (DOR), time to progression (TTP), time to response, respectability, safety and tolerability of the two different treatment arms.
Eligibility:
Inclusion/Exclusion : (key criteria)
- Histologically or cytologically –confirmed adenocarcinoma of the colon or rectum, with unresectable disease
- Measurable disease
- Must have wild-type KRAS tumor status
- No brain metastasis allowed
Treatment:
Panitumumab is provided by study
- Arm 1:
- Panitumumab 6mg/kg, day 1, every 2 weeks
- Oxaliplatin 85 mg/m2, day, every 2 weeks
- Leucovorin 400mg/m2, day 1, every 2 weeks
- 5-FU 400mg/m2 bolus, day 1, every 2 weeks
- 5-FU 2400mg/m2 continuous, day 1, every 2 weeks
- Arm 2:
- Bevacizumab 5mg/kg, day 1, every 2 weeks
- Oxaliplatin 85 mg/m2, day, every 2 weeks
- Leucovorin 400mg/m2, day 1, every 2 weeks
- 5-FU 400mg/m2 bolus, day 1, every 2 weeks
- 5-FU 2400mg/m2 continuous, day 1, every 2 weeks
Contact:
Call Avitra Bone, RN @ 256-705-4283 for more information
Current Clinical Trials:
If you are interested in more information on clinical trials at Clearview, please feel free to contact us (256) 705-4224. More information regarding clinical trials can be found at: www.ClinicalTrials.gov