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New study backs Avastin in lung cancer
July 21, 2010
Last Updated: 2010-07-20 11:30:31 -0400 (Reuters Health)LONDON (Reuters) - The drug Avastin won a renewed endorsement as a treatment for lung cancer on Tuesday from a clinical study looking at the drug's use in a broad, real-life setting.
The outcome of the Phase IV study by Lucio Crino of the Hospital Santa Maria della Misericordia in Perugia, Italy, was significant because there have been concerns about the safety of Avastin in lung cancer and doubts among some doctors on its use.
After studying 2,212 patients who were given Avastin on top of various types of chemotherapy, Crino and colleagues found no new safety problems and concluded that previously known toxicities, such as bleeding, were no more common in this broad population than among patients in earlier Phase III tests.
"The study findings confirm the well established and manageable safety profile of bevacizumab (Avastin)," they wrote in the journal Lancet Oncology.
Outside commentator Robert Pirker at the Medical University of Vienna said the findings were "reassuring" and showed that Avastin could be used safely in properly selected patients with advanced non-squamous non-small-cell lung cancer.
Avastin, from drugmaker Roche, is being reviewed this week by a U.S. advisory panel that is considering whether or not its clinical benefit has been demonstrated in breast cancer.
SOURCE: http://link.reuters.com/run58m Lancet Oncology, online July 20, 2010.
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